Other drugs may interact with fentanyl, including prescription and over-the-counter medicines, vitamins, and herbal products. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 5 Nov 2023), Cerner Multum™ (updated 24 Oct 2023), ASHP (updated 12 Nov 2023) and others. Opioid-dependent individuals sometimes use fentanyl as a substitute for heroin. However, it is a very dangerous substitute because of its marked potency and the inability for people to gauge dosages, resulting in frequent deadly overdoses.

  • Additionally, some studies include people who have expired while others exclude people who are unable to answer questions.
  • Finally, the N-methyl-D-aspartate receptor antagonist esketamine improved remifentanil-induced respiratory depression in one double-blind, placebo-controlled study (Jonkman et al. 2018).
  • More recently, studies reported that IV GAL021 (Galleon Pharmaceuticals Corp.), a calcium-activated potassium channel blocker was able to reverse alfentanil-induced respiratory depression, with few adverse events (Roozekrans et al. 2015, 2014).
  • This also explains why tolerance to this drug can develop so quickly, increasing a person’s risk of addiction.

If you switch to fentanyl nasal spray from another form of fentanyl, you will not use the same dose. Fentanyl sublingual spray should be used together with other non-fentanyl narcotic pain medicines that are used around the clock. Do not change to another form of fentanyl eg injection, skin patch, dissolving film, or “lollipop” device. If you switch from another form of fentanyl, you will not use the same dose.

How many people are dying from it?

The count of peak car crash deaths in 1972 is adjusted slightly to account for changes in the way deaths are categorized under the International Classification of Diseases. The majority of mothers include some formula in their babies’ diet by the time they reach six months. But the current shortage of infant formula is inciting terror in many parents who are struggling to nourish their babies. Some are pushing harder for mothers to breastfeed, which can be emotionally and physically grueling, if not impossible, for many women for many reasons.

fentanyl overdose

If you have fentanyl on your hands and then touch your eyes, nose or mouth, it could be possible to ingest the substance and bring it into your bloodstream, Marino and Stolbach said. To prevent accidentally ingesting fentanyl, Stolbach recommended taking reasonable precautions how long does fentanyl stay in your system like “wearing gloves” and “washing powder off hands” if you come in contact with the substance. Grapefruit and grapefruit juice may interact with fentanyl and lead to unwanted side effects. Avoid driving or operating machinery until you know how this medicine will affect you.

Treatment of opioid overdose: current approaches and recent advances

When officers announce a seizure of fentanyl, it’s not unusual for the drug to be quantified as enough to kill a large number of people. On Nov. 8, 2023, several county elections offices in Washington state were evacuated after they received envelopes containing suspicious powder — including two that field-tested positive for fentanyl — while workers were processing ballots from the election the day before. A senior U.S. official familiar with the investigation told CBS News that roughly a dozen letters were sent to addresses in California, Georgia, Nevada and Oregon as well as Washington state. Long-term use of opioid medication may affect fertility (ability to have children) in men or women.

Partly, it’s because fentanyl is a dangerous drug and people have limited information on how it works. It’s also because the people spreading the myth are “people without the appropriate medical training” who are sharing what Vakharia called “well-intentioned” but incorrect information. However, experts in the fields of toxicology and public health have told CBS News that just touching or being near fentanyl won’t cause an overdose. If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born.

Deaths involving illicitly manufactured fentanyl are on the rise

A few case reports and one pilot study have also indicated that buprenorphine can be used as a treatment for opioid overdose. Arkansas, Florida, Hawaii, Illinois, Indiana, Louisiana, Missouri, and Washington reported deaths from counties that accounted for ≥75% of drug overdose deaths in the state in 2017, per SUDORS funding requirements; all other jurisdictions reported deaths from the full jurisdiction. Jurisdictions were included if data were available for at least one 6-month period (July–December 2019, January–June 2020, July–December 2020, January–June 2021, or July–December 2021), and coroner and medical examiner reports were available for ≥75% of deaths in the included period or periods. Analysis was restricted to decedents with an available coroner or medical examiner report.

  • WHO supports countries in their efforts to ensure rational use of opioids and  their optimal availability for medical purposes and minimization of their misuse and non-medical use.
  • The severity of the injury is determined by how long the brain goes without sufficient oxygen.
  • The patch works by slowly releasing fentanyl through the skin into the bloodstream over 20–72 hours.
  • Deaths due to opioid overdoses have risen sharply in the past few years, partly due to a particularly potent drug called fentanyl.
  • Discuss this information and any questions you have with your doctor or other health care provider.

In the 1950s, the opioid receptor antagonists nalorphine and levallorphan were used to reverse opioid-induced respiratory depression; however, when administered alone, these drugs could also cause respiratory depression (Foldes et al. 1969; Thomas and Tenney 1955). Naloxone hydrochloride was developed in the 1960s and was the first opioid receptor antagonist capable of reducing opioid-induced respiratory depression without producing opioid receptor agonist effects. The FDA approved naloxone in 1971 (U.S. Food and Drug Administration, NDA 016,636), and it is now the most widely used opioid overdose reversal agent. Naloxone was almost exclusively administered in the hospital setting by trained clinical professionals until 1996 when the Chicago Recovery Alliance program became the first opioid overdose prevention program to distribute naloxone to the community (Any Positive Change 2021). Jurisdictions were included if data were available for at least one 6-month period (July–December 2019, January–June 2020, July–December 2020, January–June 2021, or July–December 2021). The term “opioids” includes compounds that are extracted from the poppy plant (Papaver somniferum) as well as semisynthetic and synthetic compounds with similar properties that can interact with opioid receptors in the brain.